If you've spent any time on skincare TikTok this year, you've probably seen the words "salmon DNA" or, more alarmingly, "salmon sperm facial". It sounds like a gimmick. It isn't quite one, but it's also not the miracle some brands make it out to be. Here's what PDRN actually is, what the science says, and what you can realistically expect from it in a serum or cream.
So what is PDRN?
PDRN stands for polydeoxyribonucleotide. That's a mouthful, but it just means a mixture of small DNA fragments. Most PDRN used in skincare is extracted from the reproductive cells of salmon and trout, then heavily purified so that only the DNA fragments are left. So no, you're not putting fish on your face, and it doesn't smell of anything.
On an ingredients list you'll usually see it written as Sodium DNA. That's the name to look for if you want to check whether a product really contains it.
A few brands are now making "vegan" or "bioengineered" PDRN through fermentation instead of from fish. It's the same type of molecule; only the source is different.
Where did it come from?
PDRN wasn't invented for beauty. It was first used in medicine, mainly as an injection to help with wound and tissue healing. Korean skin clinics then started using it in injectable "skin boosters", and that's where the trend really took off. From there it made its way into serums, creams and masks, first in K-beauty and now pretty much everywhere.
How does it work?
In lab and clinical studies, PDRN works mainly by switching on a receptor on skin cells called the adenosine A2A receptor. That signal is linked to calmer, less inflamed skin and to the cells that keep skin firm and bouncy doing their job. It's one of the better-understood "trend" ingredients, which is part of why dermatologists take it seriously.
The honest bit: injections vs serums
Here's what a lot of brands won't tell you. Almost all of the impressive results you read about come from PDRN that's been injected or used straight after microneedling in a clinic. That's because PDRN fragments are big molecules, and healthy skin is very good at keeping big molecules out.
That doesn't mean a PDRN serum does nothing. It means you should expect skincare results, not clinic results. Applied to the skin, PDRN is very gentle, it hydrates, and it pairs well with ingredients like peptides and niacinamide that help with smoothness and tone. Think of it as a good everyday ingredient for healthy-looking, glowy skin rather than a replacement for a treatment.
We'd rather tell you that now than have you feel let down later.
What can PDRN skincare help with?
- Hydration and bounce: skin that feels plumper and less tight, especially after cleansing.
- A healthier-looking glow: smoother-looking texture over a few weeks of regular use.
- Calm, comfortable skin: it's well tolerated, so it suits most skin types, including sensitive skin.
Results build up with consistency. Use it morning and night for at least four weeks before you decide whether it's working for you.
Who is it good for?
PDRN suits most people, which is one reason it's become so popular. It's a good pick if your skin feels dry or dull, if you want something gentle alongside stronger actives like retinol, or if you're simply after that dewy "glass skin" finish.
The one group who should skip it: anyone with a fish allergy. Always patch test any new product on a small area first.
How to use PDRN in your routine
- Cleanse as normal.
- Apply a serum while your skin is still slightly damp. Two or three drops is plenty for your whole face. Our PDRN Peptide Serum pairs PDRN with peptides and absorbs quickly, so it sits nicely under makeup.
- Seal it in with a moisturiser. The PDRN Collagen Jelly Cream is a light gel-cream with 5% niacinamide, so it won't feel heavy.
- SPF in the morning, always. No serum can make up for skipping sunscreen.
Once or twice a week, you can swap the moisturiser step for a Collagen Facial Mask for an extra boost of hydration. We've written a full guide on how to use a collagen gel mask if you've never tried one.
Can I use PDRN with retinol, vitamin C or acids?
Yes. PDRN plays well with most ingredients. If you use strong exfoliating acids (like glycolic acid), it's kinder to use them on different nights to your actives. If you're new to retinol, PDRN is a nice, soothing partner for it. Have a look at our retinol for beginners guide before you start.
The bottom line
PDRN is a genuinely interesting ingredient with real science behind it. In a serum or cream, it's best thought of as a gentle, hydrating, glow-boosting step rather than a wonder product. Used consistently, alongside good basics like moisturiser and SPF, it can make a lovely difference to how your skin looks and feels.
If you want to try it the easy way, our Glass Skin Ritual pairs the PDRN serum with collagen gel masks in one set.
This article is for general information and isn't medical advice. If you have a skin condition or are unsure whether a product is right for you, speak to a pharmacist or dermatologist.